| NCAAF | 11/04 17:00 | 1 | Methodist Monarchs v Lagrange Panthers | L | 38-27 | |
| NCAAF | 10/28 19:00 | 1 | Lagrange Panthers v Brevard Tornados | L | 20-30 | |
| NCAAF | 10/21 17:00 | 1 | Maryville Scots v Lagrange Panthers | L | 26-6 | |
| NCAAF | 10/14 17:00 | 1 | Lagrange Panthers v Belhaven Blazers | L | 20-42 | |
| NCAAF | 10/07 17:00 | 1 | Lagrange Panthers v Nc Wesleyan Battling Bishops | L | 14-35 | |
| NCAAF | 09/30 17:00 | 1 | Southern Virginia Knights v Lagrange Panthers | L | 52-26 | |
| NCAAF | 09/23 17:00 | 1 | Lagrange Panthers v Huntingdon Hawks | L | 6-41 | |
| NCAAF | 09/16 16:00 | 1 | Ferrum Panthers v Lagrange Panthers | L | 13-10 | |
| NCAAF | 09/09 22:00 | 1 | Lagrange Panthers v Berry Vikings | L | 3-70 | |
| NCAAF | 11/12 19:00 | 1 | Huntingdon Hawks v Lagrange Panthers | L | 55-7 | |
| NCAAF | 11/05 17:00 | 1 | Lagrange Panthers v Southern Virginia Knights | L | 21-35 | |
| NCAAF | 10/29 00:00 | 1 | Belhaven Blazers v Lagrange Panthers | L | 70-16 | |
| NCAAF | 10/22 19:00 | 1 | Brevard Tornados v Lagrange Panthers | L | 24-10 | |
| NCAAF | 10/08 17:00 | 1 | Lagrange Panthers v Maryville Scots | L | 17-56 | |
| NCAAF | 09/30 17:00 | 1 | Nc Wesleyan Battling Bishops v Lagrange Panthers | L | 37-22 | |
| NCAAF | 09/24 17:00 | 1 | Lagrange Panthers v Methodist Monarchs | L | 28-38 | |
| NCAAF | 09/17 17:00 | 1 | Lagrange Panthers v Ferrum Panthers | W | 44-38 | |
| NCAAF | 09/10 22:00 | 1 | Berry Vikings v Lagrange Panthers | L | 56-10 | |
| NCAAF | 11/13 18:00 | 1 | Lagrange Panthers v Huntingdon Hawks | L | 9-55 | |
| NCAAF | 11/06 17:00 | 1 |
Averett Cougars
v
Lagrange Panthers
|
L | 31-22 | |
| NCAAF | 10/30 17:00 | 1 | Lagrange Panthers v Greensboro Pride | W | 29-14 | |
| NCAAF | 10/23 18:00 | 1 | Maryville Scots v Lagrange Panthers | L | 52-16 | |
| NCAAF | 10/16 20:00 | 1 | Lagrange Panthers v Brevard Tornados | L | 10-20 | |
| NCAAF | 10/09 17:00 | 1 | Methodist Monarchs v Lagrange Panthers | L | 34-17 | |
| NCAAF | 09/25 17:00 | 1 | Lagrange Panthers v Nc Wesleyan Battling Bishops | L | 21-26 | |
| NCAAF | 09/18 17:00 | 1 | Southern Virginia Knights v Lagrange Panthers | W | 34-38 | |
| NCAAF | 09/11 18:00 | 1 | Lagrange Panthers v Berry Vikings | L | 21-34 | |
| NCAAF | 09/04 23:00 | 1 | Birmingham Southern Panthers v Lagrange Panthers | L | 42-17 | |
| NCAAF | 11/16 18:00 | 1 | Lagrange Panthers v Huntingdon Hawks | L | 21-45 | |
| NCAAF | 11/09 18:00 | 1 | Methodist Monarchs v Lagrange Panthers | L | 37-33 |