| NCAAF | 11/11 17:00 | 1 | Moravian Greyhounds v Wilkes Colonels | W | 6-41 | |
| NCAAF | 11/04 16:00 | 1 | Wilkes Colonels v Catholic Cardinals | L | 35-40 | |
| NCAAF | 10/21 17:00 | 1 | Susquehanna Crusaders v Wilkes Colonels | L | 34-7 | |
| NCAAF | 10/14 16:00 | 1 | Wilkes Colonels v Keystone Giants | W | 42-7 | |
| NCAAF | 10/07 16:00 | 1 | Lycoming Warriors v Wilkes Colonels | W | 35-48 | |
| NCAAF | 09/30 16:00 | 1 | Wilkes Colonels v Juniata Eagles | W | 63-14 | |
| NCAAF | 09/23 20:00 | 1 | St John Fisher Cardinals v Wilkes Colonels | L | 29-20 | |
| NCAAF | 09/16 16:00 | 1 | Wilkes Colonels v Brockport Golden Eagles | L | 7-31 | |
| NCAAF | 09/09 16:00 | 1 | Rpi Engineers v Wilkes Colonels | L | 38-14 | |
| NCAAF | 09/02 16:00 | 1 | Wilkes Colonels v Kings Monarchs | L | 23-27 | |
| NCAAF | 11/12 17:00 | 1 | Wilkes Colonels v Kings Monarchs | W | 58-42 | |
| NCAAF | 11/05 16:00 | 1 | Stevenson Mustangs v Wilkes Colonels | L | 28-0 | |
| NCAAF | 10/29 16:00 | 1 | Wilkes Colonels v Lycoming Warriors | W | 24-7 | |
| NCAAF | 10/22 17:00 | 1 | Delaware Valley Aggies v Wilkes Colonels | L | 27-14 | |
| NCAAF | 10/15 16:00 | 1 | Wilkes Colonels v Misericordia Cougars | W | 28-0 | |
| NCAAF | 10/08 16:00 | 1 |
Alvernia Golden Wolves
v
Wilkes Colonels
|
W | 14-35 | |
| NCAAF | 10/01 16:00 | 1 | Wilkes Colonels v Albright Lions | W | 27-0 | |
| NCAAF | 09/24 17:00 | 1 | Lebanon Valley Flying Dutchmen v Wilkes Colonels | L | 24-19 | |
| NCAAF | 09/17 16:00 | 1 | Wilkes Colonels v Widener Pride | W | 44-20 | |
| NCAAF | 09/03 17:00 | 1 | Keystone Giants v Wilkes Colonels | W | 21-48 | |
| NCAAF | 11/13 17:00 | 1 | Kings Monarchs v Wilkes Colonels | L | 34-7 | |
| NCAAF | 11/06 17:00 | 1 | Wilkes Colonels v Delaware Valley Aggies | L | 0-30 | |
| NCAAF | 10/30 17:00 | 1 | Lycoming Warriors v Wilkes Colonels | L | 30-27 | |
| NCAAF | 10/23 17:00 | 1 | Wilkes Colonels v Lebanon Valley Flying Dutchmen | W | 30-20 | |
| NCAAF | 10/16 17:00 | 1 | Widener Pride v Wilkes Colonels | L | 30-13 | |
| NCAAF | 10/09 16:00 | 1 | Albright Lions v Wilkes Colonels | W | 28-31 | |
| NCAAF | 10/02 16:00 | 1 | Wilkes Colonels v Stevenson Mustangs | W | 21-14 | |
| NCAAF | 09/25 17:00 | 1 |
Wilkes Colonels
v
Alvernia Golden Wolves
|
W | 23-0 | |
| NCAAF | 09/18 17:00 | 1 | Misericordia Cougars v Wilkes Colonels | W | 15-35 | |
| NCAAF | 09/04 17:00 | 1 | Wilkes Colonels v Keystone Giants | W | 46-7 |