| NCAAF | 11/11 17:00 | 1 | Moravian Greyhounds v Wilkes Colonels | W | 6-41 | |
| NCAAF | 11/04 16:00 | 1 | Wilkes Colonels v Catholic Cardinals | L | 35-40 | |
| NCAAF | 10/21 17:00 | 1 | Susquehanna Crusaders v Wilkes Colonels | L | 34-7 | |
| NCAAF | 10/14 16:00 | 1 | Wilkes Colonels v Keystone Giants | W | 42-7 | |
| NCAAF | 10/07 16:00 | 1 | Lycoming Warriors v Wilkes Colonels | W | 35-48 | |
| NCAAF | 09/30 16:00 | 1 | Wilkes Colonels v Juniata Eagles | W | 63-14 | |
| NCAAF | 09/23 20:00 | 1 | St John Fisher Cardinals v Wilkes Colonels | L | 29-20 | |
| NCAAF | 09/16 16:00 | 1 | Wilkes Colonels v Brockport Golden Eagles | L | 7-31 | |
| NCAAF | 09/09 16:00 | 1 | Rpi Engineers v Wilkes Colonels | L | 38-14 | |
| NCAAF | 09/02 16:00 | 1 | Wilkes Colonels v Kings Monarchs | L | 23-27 | |
| NCAAF | 11/12 17:00 | 1 | Wilkes Colonels v Kings Monarchs | W | 58-42 | |
| NCAAF | 11/05 16:00 | 1 | Stevenson Mustangs v Wilkes Colonels | L | 28-0 |