Estadio: Jack Britt Memorial Stadium Round: 1
| NCAAF | 2022/11/05 20:00 | Lake Erie v Ashland Eagles | L | 23-31 |
| NCAAF | 2022/10/29 16:00 | Findlay Oilers v Lake Erie | L | 42-17 |
| NCAAF | 2022/10/22 18:00 | Lake Erie v Northwood Timberwolves | W | 21-18 |
| NCAAF | 2022/10/15 16:00 | Walsh University Cavaliers v Lake Erie | W | 15-22 |
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | L | 7-38 |
| NCAAF | 2022/10/01 20:00 | Tiffin Dragons v Lake Erie | L | 52-27 |
| NCAAF | 2022/09/24 18:00 | Southwest Baptist University Bearcats v Lake Erie | L | 52-31 |
| NCAAF | 2022/09/17 22:00 | Lake Erie v McKendree | L | 37-38 |
| NCAAF | 2022/11/05 17:00 | Northern Michigan Wildcats v Saginaw Valley State Cardinals | L | 21-30 |
| NCAAF | 2022/10/29 17:00 | Northern Michigan Wildcats v Ferris State | L | 20-56 |
| NCAAF | 2022/10/22 19:00 | Grand Valley State v Northern Michigan Wildcats | L | 56-3 |
| NCAAF | 2022/10/15 17:00 | Michigan Technological University Huskies v Northern Michigan Wildcats | L | 21-7 |
| NCAAF | 2022/10/08 17:00 | Northern Michigan Wildcats v Davenport Panthers | L | 24-27 |
| NCAAF | 2022/10/01 22:00 | Wayne State Warriors Football v Northern Michigan Wildcats | W | 30-37 |
| NCAAF | 2022/09/24 18:00 | Northern Michigan Wildcats v Post University Eagles | W | 42-14 |
| NCAAF | 2022/09/17 16:00 | Davenport Panthers v Northern Michigan Wildcats | L | 31-21 |