Estadio: Franklin Field Round: 1
Home Manager: Ray Priore Away Manager: John Troxell
| NCAAF | 2021/09/25 19:30 | Pennsylvania v Lafayette | W | 14-24 |
| NCAAF | 2019/09/28 19:30 | Pennsylvania v Lafayette | L | 28-24 |
| NCAAF | 2022/09/17 23:30 | Lafayette v Rice | L | 21-33 |
| NCAAF | 2022/09/17 19:30 | William & Mary v Lafayette | L | 34-7 |
| NCAAF | 2022/09/10 23:00 | Eastern Michigan v Lafayette | W | 21-49 |
| NCAAF | 2022/09/10 18:00 | Lafayette v Temple | L | 14-30 |
| NCAAF | 2022/09/03 23:00 | SE Louisiana Lions v Lafayette | W | 7-24 |
| NCAAF | 2022/09/03 16:30 | Sacred Heart v Lafayette | W | 0-6 |
| NCAAF - Encuentros de bowl | 2021/12/19 02:15 | Marshall v Lafayette | W | 21-36 |
| NCAAF | 2021/12/04 20:30 | Appalachian St v Lafayette | W | 16-24 |
| NCAAF | 2022/09/17 17:00 | Colgate v Pennsylvania | W | 14-25 |
| NCAAF | 2021/11/20 18:00 | Princeton v Pennsylvania | L | 34-14 |
| NCAAF | 2021/11/13 17:00 | Pennsylvania v Harvard | L | 7-23 |
| NCAAF | 2021/11/06 17:00 | Cornell Big Red v Pennsylvania | L | 15-12 |
| NCAAF | 2021/10/30 17:00 | Brown v Pennsylvania | W | 17-45 |
| NCAAF | 2021/10/23 16:00 | Pennsylvania v Yale | L | 28-42 |
| NCAAF | 2021/10/16 17:30 | Pennsylvania v Columbia | L | 14-23 |
| NCAAF | 2021/10/09 17:00 | Lehigh Mountain Hawks v Pennsylvania | W | 0-20 |