Head to Head
| México - Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlán F.C. | L | 1-0 |
| México - Liga MX | 2021/01/23 03:30 | Mazatlán F.C. v Santos Laguna | D | 0-0 |
| México - Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlán F.C. | L | 4-0 |
| México - Liga MX | 2016/07/31 23:00 | Santos Laguna v Mazatlán F.C. | W | 2-4 |
| México - Liga MX | 2016/05/01 01:30 | Mazatlán F.C. v Santos Laguna | W | 3-2 |
| México - Liga MX | 2015/11/07 03:30 | Santos Laguna v Mazatlán F.C. | W | 2-3 |
| México - Liga MX | 2015/04/04 01:30 | Mazatlán F.C. v Santos Laguna | L | 0-1 |
| México - Liga MX | 2014/10/05 01:00 | Santos Laguna v Mazatlán F.C. | D | 2-2 |
Home History
| México - Liga MX | 2022/01/22 03:00 | Mazatlán F.C. v Toluca | L | 1-2 |
| México - Liga MX | 2022/01/10 00:00 | Chivas de Guadalajara v Mazatlán F.C. | L | 3-0 |
| México - Liga MX | 2021/11/06 03:00 | Mazatlán F.C. v Chivas de Guadalajara | L | 0-1 |
| México - Liga MX | 2021/10/30 00:00 | Necaxa v Mazatlán F.C. | L | 2-1 |
| México - Liga MX | 2021/10/23 02:00 | Mazatlán F.C. v Querétaro | W | 2-1 |
| México - Liga MX | 2021/10/20 00:00 | Puebla v Mazatlán F.C. | L | 2-0 |
| México - Liga MX | 2021/10/16 02:00 | Mazatlán F.C. v Atlas | W | 1-0 |
| México - Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlán F.C. | L | 1-0 |
Away History
| México - Liga MX | 2022/01/24 01:00 | Santos Laguna v Necaxa | L | 1-4 |
| México - Liga MX | 2022/01/16 18:00 | Toluca v Santos Laguna | L | 3-1 |
| México - Liga MX | 2022/01/13 02:06 | Santos Laguna v Tigres UANL | D | 1-1 |
| México - Liga MX | 2021/11/29 00:00 | Tigres UANL v Santos Laguna | L | 1-0 |
| México - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | W | 2-1 |
| México - Liga MX | 2021/11/21 01:00 | Santos Laguna v Atlético San Luis | W | 2-0 |
| México - Liga MX | 2021/11/08 01:06 | Santos Laguna v Atlético San Luis | D | 0-0 |
| México - Liga MX | 2021/11/05 01:00 | Pumas de la UNAM v Santos Laguna | W | 0-3 |