[14] Santos Laguna 1-1 Querétaro [16] 2022-04-17 00:00
Estadio: Estadio TSM Corona Round: 14
Árbitro: Cesar Arturo Ramos Home Manager: Eduardo Fentanes Away Manager: Hernan Cristante
Head to Head
| México - Liga MX | 2021/10/30 22:00 | Querétaro v Santos Laguna | W | 2-3 |
| México - Liga MX | 2021/05/09 02:15 | Santos Laguna v Querétaro | W | 5-0 |
| México - Liga MX | 2021/04/12 00:00 | Querétaro v Santos Laguna | L | 1-0 |
| México - Liga MX | 2020/08/31 00:06 | Santos Laguna v Querétaro | W | 2-1 |
| México - Liga MX | 2019/10/30 01:00 | Santos Laguna v Querétaro | W | 1-0 |
| México - Liga MX | 2019/04/21 23:06 | Santos Laguna v Querétaro | W | 2-1 |
| México - Liga MX | 2018/11/04 22:00 | Querétaro v Santos Laguna | L | 2-1 |
| México - Liga MX | 2018/04/08 23:00 | Santos Laguna v Querétaro | W | 3-0 |
Home History
| México - Liga MX | 2022/04/10 00:06 | Monterrey v Santos Laguna | L | 1-0 |
| México - Liga MX | 2022/04/04 00:00 | Santos Laguna v Pachuca | W | 3-1 |
| México - Liga MX | 2022/03/19 03:00 | Puebla v Santos Laguna | D | 2-2 |
| México - Liga MX | 2022/03/14 01:00 | Santos Laguna v Tijuana | W | 4-0 |
| México - Liga MX | 2022/03/06 03:00 | Chivas de Guadalajara v Santos Laguna | L | 1-0 |
| México - Liga MX | 2022/03/03 03:00 | Santos Laguna v Pumas de la UNAM | W | 3-2 |
| México - Liga MX | 2022/02/28 01:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| CONCACAF - Copa de Campeones | 2022/02/24 01:15 | CF Montréal v Santos Laguna | L | 3-0 |
Away History
| México - Liga MX | 2022/04/11 00:00 | Querétaro v Tigres UANL | L | 0-1 |
| México - Liga MX | 2022/04/03 22:00 | León v Querétaro | D | 1-1 |
| México - Liga MX | 2022/03/18 03:05 | Querétaro v Atlético San Luis | W | 2-1 |
| México - Liga MX | 2022/03/12 01:00 | Necaxa v Querétaro | L | 1-0 |
| México - Liga MX | 2022/03/02 03:00 | Club América v Querétaro | D | 1-1 |
| México - Liga MX | 2022/02/25 03:05 | Querétaro v Toluca | D | 1-1 |
| México - Liga MX | 2022/02/19 23:00 | Querétaro v Mazatlán F.C. | W | 2-0 |
| México - Liga MX | 2022/02/15 03:00 | Pachuca v Querétaro | D | 2-2 |