[2] Puebla 2-2 Santos Laguna [11] 2022-03-19 03:00
Estadio: Estadio Cuauhtémoc Round: 11
Árbitro: Fernando Guerrero Home Manager: Nicolas Larcamon Away Manager: Eduardo Fentanes
Head to Head
| México - Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| México - Liga MX | 2021/05/24 00:00 | Puebla v Santos Laguna | W | 1-0 |
| México - Liga MX | 2021/05/21 02:00 | Santos Laguna v Puebla | L | 3-0 |
| México - Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |
| México - Liga MX | 2020/10/03 00:30 | Puebla v Santos Laguna | L | 0-2 |
| México - Liga MX | 2020/02/08 03:00 | Puebla v Santos Laguna | D | 2-2 |
| México - Liga MX | 2019/08/11 23:45 | Santos Laguna v Puebla | L | 4-1 |
| México - Liga MX | 2019/01/19 03:00 | Puebla v Santos Laguna | D | 1-1 |
Home History
| México - Liga MX | 2022/03/13 23:00 | Atlético San Luis v Puebla | L | 2-1 |
| México - Liga MX | 2022/03/06 03:00 | Cruz Azul v Puebla | W | 1-3 |
| México - Liga MX | 2022/03/02 01:00 | Puebla v Juárez FC | D | 1-1 |
| México - Liga MX | 2022/02/27 01:00 | Chivas de Guadalajara v Puebla | W | 2-3 |
| México - Liga MX | 2022/02/19 01:00 | Puebla v Monterrey | W | 1-0 |
| México - Liga MX | 2022/02/12 03:00 | Puebla v Atlas | D | 1-1 |
| México - Liga MX | 2022/02/06 22:00 | Querétaro v Puebla | W | 0-2 |
| México - Liga MX | 2022/01/29 03:00 | Puebla v Tijuana | W | 3-1 |
Away History
| México - Liga MX | 2022/03/14 01:00 | Santos Laguna v Tijuana | W | 4-0 |
| México - Liga MX | 2022/03/06 03:00 | Chivas de Guadalajara v Santos Laguna | L | 1-0 |
| México - Liga MX | 2022/03/03 03:00 | Santos Laguna v Pumas de la UNAM | W | 3-2 |
| México - Liga MX | 2022/02/28 01:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| CONCACAF - Copa de Campeones | 2022/02/24 01:15 | CF Montréal v Santos Laguna | L | 3-0 |
| México - Liga MX | 2022/02/19 03:00 | Juárez FC v Santos Laguna | D | 0-0 |
| CONCACAF - Copa de Campeones | 2022/02/16 03:00 | Santos Laguna v CF Montréal | W | 1-0 |
| México - Liga MX | 2022/02/13 03:00 | Santos Laguna v Club América | L | 2-3 |