Estadio: Strawberry Stadium Round: 1
Home Manager: Frank Scelfo Away Manager: Willie Simmons
| NCAAF | 2021/11/20 20:30 | Florida A&M v Bethune Cookman | W | 46-21 |
| NCAAF | 2021/11/13 20:00 | Florida A&M v Arkansas Pine Bluff | W | 37-7 |
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | W | 29-17 |
| NCAAF | 2021/10/30 20:00 | Grambling State v Florida A&M | W | 3-26 |
| NCAAF | 2021/10/23 20:00 | Florida A&M v Mississippi Valley State | W | 31-28 |
| NCAAF | 2021/10/16 18:00 | Florida A&M v Alabama | W | 35-31 |
| NCAAF | 2021/10/09 22:00 | South Carolina State Bulldogs v Florida A&M | W | 7-30 |
| NCAAF | 2021/10/02 22:00 | Alabama State v Florida A&M | W | 0-28 |
| NCAAF | 2021/11/19 00:00 | Nicholls Colonels v SE Louisiana Lions | L | 45-42 |
| NCAAF | 2021/11/14 00:00 | Northwestern State v SE Louisiana Lions | W | 28-56 |
| NCAAF | 2021/11/06 19:00 | SE Louisiana Lions v Incarnate Word | L | 52-55 |
| NCAAF | 2021/10/30 23:00 | McNeese State Cowboys v SE Louisiana Lions | W | 20-23 |
| NCAAF | 2021/10/23 20:00 | SE Louisiana Lions v Northwestern State | W | 51-14 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana Lions | W | 24-61 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana Lions v Nicholls Colonels | W | 58-48 |
| NCAAF | 2021/10/02 17:00 | SE Louisiana Lions v McNeese State Cowboys | W | 38-35 |