Estadio: Fisher Stadium Round: 1
Home Manager: John Garrett Away Manager: Ray Priore
| NCAAF | 2021/09/18 22:00 | Pennsylvania v Bucknell | W | 30-6 |
| NCAAF | 2019/11/23 18:00 | Princeton v Pennsylvania | L | 28-7 |
| NCAAF | 2019/11/16 17:00 | Pennsylvania v Harvard | W | 24-20 |
| NCAAF | 2019/11/09 18:30 | Cornell Big Red v Pennsylvania | W | 20-21 |
| NCAAF | 2019/11/02 17:00 | Brown v Pennsylvania | W | 36-38 |
| NCAAF | 2019/10/26 16:00 | Pennsylvania v Yale | L | 41-46 |
| NCAAF | 2019/10/19 17:30 | Pennsylvania v Columbia | L | 6-44 |
| NCAAF | 2019/10/12 17:00 | Sacred Heart v Pennsylvania | W | 24-38 |
| NCAAF | 2021/09/18 16:30 | New Hampshire v Lafayette | L | 19-13 |
| NCAAF | 2021/09/17 00:00 | Ohio v Lafayette | W | 14-49 |
| NCAAF | 2021/09/11 23:00 | Nicholls Colonels v Lafayette | W | 24-27 |
| NCAAF | 2021/09/11 22:00 | Lafayette v William & Mary | L | 3-24 |
| NCAAF | 2021/09/04 20:30 | Lafayette v Texas | L | 18-38 |
| NCAAF | 2021/09/04 18:00 | Lafayette v Air Force | L | 14-35 |
| NCAAF | 2021/04/10 16:30 | Lehigh Mountain Hawks v Lafayette | W | 13-20 |
| NCAAF | 2021/03/27 20:00 | Lafayette v Bucknell | L | 13-38 |