[1] Villarreal 0-2 Manchester United [2] 2021-11-23 17:45
Estadio: Estadio de la Cerámica Round: 5
Árbitro: Felix Brych Home Manager: Unai Emery Away Manager: Ole Gunnar Solskjaer
Head to Head
| UEFA Champions League | 2021/09/29 19:00 | Manchester United v Villarreal | L | 2-1 |
| UEFA Europa League | 2021/05/26 19:00 | Villarreal v Manchester United | W | 12-11 |
Home History
| España - 1ª División | 2021/11/20 13:00 | Celta de Vigo v Villarreal | D | 1-1 |
| España - 1ª División | 2021/11/07 13:00 | Villarreal v Getafe | W | 1-0 |
| UEFA Champions League | 2021/11/02 20:00 | Villarreal v Young Boys | W | 2-0 |
| España - 1ª División | 2021/10/30 16:30 | Valencia v Villarreal | L | 2-0 |
| España - 1ª División | 2021/10/26 19:30 | Villarreal v Cádiz | D | 3-3 |
| España - 1ª División | 2021/10/23 19:00 | Athletic de Bilbao v Villarreal | L | 2-1 |
| UEFA Champions League | 2021/10/20 19:00 | Young Boys v Villarreal | W | 1-4 |
| España - 1ª División | 2021/10/17 16:30 | Villarreal v Osasuna | L | 1-2 |
Away History
| Inglaterra - Premier League | 2021/11/20 15:00 | Watford v Manchester United | L | 4-1 |
| Inglaterra - Premier League | 2021/11/06 12:30 | Manchester United v Manchester City | L | 0-2 |
| UEFA Champions League | 2021/11/02 20:00 | Atalanta v Manchester United | D | 2-2 |
| Inglaterra - Premier League | 2021/10/30 16:30 | Tottenham v Manchester United | W | 0-3 |
| Inglaterra - Premier League | 2021/10/24 15:30 | Manchester United v Liverpool | L | 0-5 |
| UEFA Champions League | 2021/10/20 19:00 | Manchester United v Atalanta | W | 3-2 |
| Inglaterra - Premier League | 2021/10/16 14:00 | Leicester v Manchester United | L | 4-2 |
| Inglaterra - Premier League | 2021/10/02 11:30 | Manchester United v Everton | D | 1-1 |